The National Institute of Biology (NIB) was proud to host researcher Dr. Marta Sendra Vega from the Department of Biotechnology and Food Sciences at the University of Burgos, Spain. As part of the CutCancer project the NIB team organized a lecture for NIB employees entitled “Biological interaction at nanoscale”, delivered by Dr. Marta Sendra Vega. Her captivating presentation explored biological interactions at the nanoscale, offering valuable insights into advanced research and its implications for nanotechnology and biology.

In the lecture Marta delves into the toxicological mechanisms of nanoplastics (NPs) and their interactions with biological systems. Through advanced research, she explores how nanoplastics are absorbed, translocated, and retained within cells, highlighting key findings on their oxidative, mitochondrial, lysosomal, and DNA damage effects. Marta also examines the role of immune system responses and the mechanisms by which NPs penetrate tissues, emphasizing their potential to cross biological barriers.

The lecture underscores the importance of in vitro and in vivo models, including the use of zebrafish and innovative 3D cell models, in studying NP behavior and toxicity. It provides insights into the molecular and cellular pathways affected by these materials and discusses their implications for environmental and human health. By addressing emerging methods and collaborative frameworks, this lecture showcases advancements in toxicological testing that align with the 3R principles (Replacement, Reduction, Refinement).