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Patient-derived tumor organoids mimic treatment-induced DNA damage response in glioblastoma

Open access: https://doi.org/10.1016/j.isci.2024.110604 Bernarda Majc, Anamarija Habič, Marta Malavolta, Miloš Vittori, Andrej Porčnik, Roman Bošnjak, Jernej Mlakar, Alenka Matjašič, Andrej Zupan, Marija Skoblar Vidmar, Tamara Lah Turnšek, Aleksander Sadikov, Barbara Breznik, Metka Novak Glioblastoma (GB) is the most common primary malignant brain tumor, characterized by resistance to therapy. Despite aggressive treatment options, GB remains an…

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EACR congress in Rotterdam June 2024

Barbara Breznik presented research work at the EACR congress in Rotterdam (10-13 June) in a form of poster presentation. She presented work, entitled »Utilizing translational platform GlioBank to identify novel molecular signatures of glioblastoma progression«.  Glioblastoma (GBM) is one of the most lethal solid tumors in humans. Currently, GBM is considered incurable and there is…

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Brain tumour meeting 2024

In May, Brain tumour meeting 2024 was held in Berlin. It was a brilliant event with great talks about brain cancer cell’ plasticity, brain metastases, tumour microenvironment, and the role of immune system in brain tumours. We are proud of PhD student Tina Kolenc Milavec, a member of our group, who attended the meeting with…

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Spatial Architecture of Myeloid and T Cells Orchestrates Immune Evasion and Clinical Outcome in Lung Cancer

open access: https://doi.org/10.1158/2159-8290.CD-23-1380 Enfield KSS, Colliver E, Lee C, Magness A, Moore DA, Sivakumar M, Grigoriadis K, Pich O, Karasaki T, Hobson PS, Levi D, Veeriah S, Puttick C, Nye EL, Green M, Dijkstra KK, Shimato M, Akarca AU, Marafioti T, Salgado R, Hackshaw A; TRACERx consortium; Jamal-Hanjani M, van Maldegem F, McGranahan N, Glass…

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Genotoxicity and heating Performance of VxFe3-xO4 nanoparticles in Health applications

open access: https://doi.org/10.1016/j.cbi.2024.110977 Sanz-Sagué B, Sáenz-Hernández A, Moreno Maldonado AC, Fuentes-García JA, Nuñez JM, Zegura B, Stern A, Kolosa K, Rozman I, Torres TE, Goya GF The applications of magnetic nanoparticles (MNPs) as biocatalysts in different biomedical areas have been evolved very recently. One of the main challenges in this field is to design affective…

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Adverse (geno)toxic effects of bisphenol A and its analogues in hepatic 3D cell model

open access: https://doi.org/10.1016/j.envint.2022.107721 Marta Sendra, Martina Štampar, Katarina Fras, Beatriz Novoa, Antonio Figueras, Bojana Žegura Bisphenol A (BPA) is one of the most widely used and versatile chemical compounds in polymer additives and epoxy resins for manufacturing a range of products for human applications. It is known as endocrine disruptor, however, there is growing evidence…

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Combined Toxic Effects of BPA and Its Two Analogues BPAP and BPC in a 3D HepG2 Cell Model

open access: https://www.mdpi.com/2223382 Štampar, M.; Ravnjak, T.; Domijan, A.-M.; Žegura, B. Bisphenol A (BPA) is one of the most commonly used substances in the manufacture of various everyday products. Growing concerns about its hazardous properties, including endocrine disruption and genotoxicity, have led to its gradual replacement by presumably safer analogues in manufacturing plastics. The widespread…

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